What are the “True” Pathogenic Anti-desmoglein Antibodies?
نویسندگان
چکیده
منابع مشابه
[Pathogenic mechanisms of the anti-phospholipid antibodies].
The antiphospolipid syndrome (APS) is an autoimmune disease characterized by recurrent fetal loss, thrombotic events (arterial or venous) and hemocytopenic disorders associated to high titers of circulating aPL. Two variants of the APS have been described. Primary APS is a clinical entity without evidence of any other autoimmune disease and secondary APS is a clinical disorder mainly associated...
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Pemphigus vulgaris (PV) is considered as a model for an autoantibody-mediated organ-specific autoimmune disorder. IgG autoantibodies directed against the desmosomal cadherin desmoglein 3 (Dsg3), the major autoantigen in PV, cause loss of epidermal keratinocyte adhesion, resulting in blisters and erosions of the skin and mucous membranes. The association of human autoimmune diseases with distinc...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2014
ISSN: 0001-5555
DOI: 10.2340/00015555-2119